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DTSTART;TZID=UTC:20260929T110000
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SUMMARY:SFB 1551 Seminar - Prof. Dr. Lennart Hilbert
DESCRIPTION:Prof. Dr. Lennart Hilbert – Karlsruhe Institute of Technology (KIT) \nWe are happy to announce the SFB 1551 Seminar on Tuesday\, 29 September 2026\, at 10:30 h. \nTitle: Engage-and-release visits to transcription hubs enable hyperactivation of zygotic genes \nSummary: \nEarly embryonic development requires robust changes between repression and transcriptional activation of genes. A central role in this regulation has been attributed to prominent transcriptional clusters\, which are established by liquid-like condensation at super-enhancers that act as condensation surfaces. In this work\, we assess how transient visits of genes to such surface condensates are related to changes in transcriptional activity over five consecutive stages of development in the early zebrafish embryo. Combining gene-specific fluorescence-labeling with automated analysis of microscopy images\, we reveal that the transcriptional status of a given gene systematically maps to the frequency of spatial association of this gene with transcriptional condensates. High levels of transcriptional poising\, where RNA polymerase II remains paused close to the promoter\, imply frequent gene-condensate association; high levels of actual transcriptional activity imply a less frequent association\, but not complete loss of association. Based on an analysis of ChIP-seq\, RNA-seq\, and Hi-C data\, the same relation of transcriptional control and gene association with super-enhancer regions appears to hold genome-wide. These experimental observations are closely reproduced by model simulations\, where a surface condensate formed on a super-enhancer region can attract and activate genes by a liquid-bridge mechanism. Finally\, simulations that sample a range of “virtual gene designs” indicate two key design parameters: enhancer-like properties of the promoter region support gene-cluster association\, while a high rate of transcriptional activation favors rapid detachment of the gene from the cluster. In summary\, the surface condensate model explains how the transcriptional control of embryonic genes can play out via sequential engagement with transcriptional hubs followed by release upon transcriptional activation. \nWe look forward to see you there! \nThe SFB1551 coordination team
URL:https://crc1551.com/our-event/sfb-1551-seminar-prof-dr-lennart-hilbert/
LOCATION:Biocentre 1 – Room 01.202\, Hanns-Dieter-Hüsch-Weg 15\, Mainz\, Rhineland-Palatinate\, 55128\, Germany
ATTACH;FMTTYPE=image/jpeg:https://crc1551.com/wp-content/uploads/2026/09/SFB1551-Seminar-Series_Lennart_Hilbert.jpg
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DTSTART;VALUE=DATE:20261011
DTEND;VALUE=DATE:20261015
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SUMMARY:SFB1551 & SPP2191 Joint Workshop on "Self-Leadership for Scientists – Look Within to Succeed.”
DESCRIPTION:SFB1551 & SPP2191 Joint Workshop “Self-Leadership for Scientists – Look Within to Succeed.”\nFollowing the very positive response to the first edition\, we are pleased to invite you to participate on the workshop\, “Self-Leadership for Scientists – Look Within to Succeed.” \nThis workshop\, originally organised by the SPP2191 network\, will be run by Melissa Davies and will explore key aspects of self-leadership\, including self-awareness\, self-confidence\, and self-efficacy. \nIt also offers a supportive space for participants to exchange ideas\, share experiences\, and discuss strategies for navigating challenging situations in the world of scientific research. \nWorkshop details \n\nDates: October 12–14\, 2026 (arrival: Sunday\, October 11\, by 6:00 p.m.\, departure: Wednesday\, October 14 after lunch)\nLocation: Hotel Beau-Site\, Valais\, Switzerland\nParticipants: Primarily aimed at women in early career stages PhD/Postdocs of the SPP2191 and SFB1551 networks\nCapacity: Limited to 14 participants (a few spots are still available)\nCosts: Registration and training as well hotel fees are covered by SFB1551 central funds. Travel expenses are not included and must be covered by you.\n\nIf you are interested in joining for the full time\, please contact the SFB1551 office\, so we can reserve a spot for you. Registrations will be handled on a first-come\, first-served basis\, prioritising funded members of Phase II. \nWe look forward to welcoming you to this event! \nYour  SFB1551 & SPP2191 Teams
URL:https://crc1551.com/our-event/sfb1551-spp2191-joint-workshop-on-self-leadership-for-scientists-look-within-to-succeed/
LOCATION:Hotel Beau-Site\, Valais\, Switzerland\, Chemin du Mont 13\, 1927 Chemin-Dessus\,\, Switzerland
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