SFB 1551

SFB 1551 Seminar Series Event - Prof. Dr. Konstanze Winklhofer
2024-02-22 10:30 - 11:30 UTC
Talk announcement for Prof. Dr. Konstanze Winklhofer

“Linear polyubiquitin as a regulator of phase transitions in signaling and protein quality control”
By Prof. Dr. Konstanze Winklhofer
Ruhr-Universität Bochum

SFB1551 Winter School
2024-03-04 09:00 - 2024-03-07 17:00 UTC | Kurpark-Hotel, Schloßplatz 1-4, Bad Dürkheim, 67098, Germany
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SFB 1551 Seminar Series Event - Prof. Dr. Ralf Metzler
2024-03-14 10:30 - 11:30 UTC
Talk announcement for Prof. Dr. Ralf Metzler.

“Long-ranged correlated processes in disordered systems”
By Prof. Dr. Ralf Metzler
Universität Potsdam
Abstract from Prof. Metzler:
Stochastic processes with long-ranged, power-law correlations naturally emerge in systems such as Rouse polymers or single-file systems, when all degrees of freedom are integrated out, apart from the (tracer) particle of interest. In non-equilibrium situations, the resulting overdamped dynamics corresponds to Mandelbrot’s fractional Brownian motion (FBM).
This talk will address some peculiar behaviours of FBM when subject to confinement in box potentials as well as sub- or superharmonic external potentials. Specifically, it will be argued why superdiffusive FBM may be a good (polymer) model for growing serotonergic fibres in the mammalian brain.
In disordered environments it will be shown how non-Gaussian displacement density functions emerge and subtly depend on how the dynamics is introduced. This is achieved by stochastic-diffusivity models connected with long-range dependent noise. Moreover, it will be discussed how time-dependent critical exponents can be introduced in this formalism.
Finally, amoeba systems will be introduced in which the displacement density function appears to converge to a non-Gaussian, Laplace density.

SFB 1551 Seminar Series Event - Prof. Dr. Jörg Höhfeld
2024-04-11 10:30 - 11:30 UTC
Talk announcement for Prof. Dr. Jörg Höhfeld.

Maintaining the proteome under mechanical stress – from mechanisms to pathology
By Prof. Dr. Jörg Höhfeld
Universität Bonn · Institut für Zellbiologie
Abstract from Prof. Höhfeld:
Organismal survival depends on the ability to maintain functional protein networks even under conditions that threaten protein integrity. Cells in multicellular organisms are constantly exposed to stress resulting from mechanical forces. In this situation, protein homeostasis relies on a chaperone machinery that is organized by the co-chaperone BAG3. The BAG3-machinery recognizes force-unfolded cytoskeleton proteins and mediates their disposal through chaperone-assisted selective autophagy (CASA). In addition, BAG3 interacts with components of the Hippo and mTOR signalling pathways to stimulate transcription and translation. This is important for compensating degradation during cytoskeleton maintenance. In agreement with its essential role under mechanical stress, BAG3 deficiency causes severe muscle weakness in children and contributes to heart failure, a leading cause of mortality in industrialized nations. Here, we discuss the mode of action of the BAG3-machinery and its force-dependent regulation and pathophysiological relevance.

SFB 1551 Seminar Series Event - Prof. Dr. Tassula Proikas-Cezanne
2024-04-25 10:30 - 11:30 UTC
Talk announcement for Prof. Dr. Tassula Proikas-Cezanne.

A role for WIPI beta propellers in autophagy and neurodegeneration
By Prof. Dr. Tassula Proikas-Cezanne
Eberhard Karls University Tübingen · Interfaculty Institute of Cell Biology (IFIZ)

SFB 1551 Seminar Series Event - Sina Wittmann
2024-05-02 10:30 - 11:30 UTC
Talk announcement for Sina Wittmann
Title: Protein condensation in the presence of nucleic acids
In the cell, many protein condensates form by nucleic acid binding proteins. This is true in the cytoplasm as well as in the nucleus. An example of the former would be RNA-binding proteins forming stress granules and of the latter the nucleolus. However, different physical phenomena can be behind these interactions. I will discuss different approaches of how to observe them experimentally.

EMBO | EMBL Symposium: Cellular mechanisms driven by phase separation
2024-05-14 08:00 - 2024-05-17 17:00 UTC | EMBL, Meyerhofstraße 1, Heidelberg, 69117
This conference will take place at EMBL Heidelberg, with the option to attend virtually.
Registration is now open! Click the link below to register for on-site or virtual attendance!
Symposium overview
Phase separation is emerging as a common biophysical basis underlying many important cellular functions. This conference will bring together scientists from soft matter, polymer physics, molecular biology, structural biology, and cell and developmental biology to study condensates in biology and disease. Goals are

to increase the awareness how important phase separation is for our understanding of many biological processes
to explore the large repertoire of new tools generated by other disciplines that are ripe to be applied to complex problems related to phase separation
to close the gap in transdisciplinary training to tackle the role of phase separation in biology

For more information please visit https://www.embl.org/about/info/course-and-conference-office/events/ees24-06/#vf-tabs__section-overview

Workshop with Prof. Heather Hofmeister (Joint Event with GenEvo, 4R, SFB1361, and SFB1551)
2024-06-06 09:30 - 13:00 UTC | IMB Seminar Room, Ackermannweg 4, Mainz, 55128, Germany
We are pleased to invite you to participate in a workshop with Prof. Heather Hofmeister entitled “Communication competencies in intercultural and intergenerational teams”.
This half-day workshop will focus on how to navigate conversations and differences in understanding each other based on different gender, cultural backgrounds, and expectations and locations in the power hierarchy and will be specifically designed for PhD students & early postdoctoral researchers from 4R, GenEvo, SFB 1361, and SFB 1551.
The workshop will be held on Thursday, June 6th, from 9:30 to 13:00, please mark your calendars!

SFB 1551 Seminar Series Event - Prof. Dr. Matthias Ballauff
2024-06-20 10:30 - 11:30 UTC
“Polyelectrolytes and Biological Systems: A Charged Relationship”
By Prof. Dr. Matthias Ballauff
Freie Universität Berlin · Institut für Chemie und Biochemie
View Abstract

SFB 1551 Seminar Series Event - Dr. Tanja Mittag & Prof. Kresten Lindorff-Larsen
2024-07-01 09:00 - 12:00 UTC
“Driving forces for phase separation, material properties and aging processes of condensates”
By Dr. Tanja Mittag
St. Jude Children’s Research Hospital · Department of Structural Biology
View abstract
“Towards structure prediction and design of disordered proteins”
By Prof. Dr. Kresten Lindorff-Larsen
Linderstrøm-Lang Centre for Protein Science · Structural Biology and NMR Laboratory
View abstract

SFB 1551 Seminar Series Event - Prof. Dr. Christian Schlieker
2024-07-08 11:00 - 12:00 UTC
“(Dis)connecting Aberrant Nuclear Condensates and Neurological Disorders”
By Prof. Dr. Christian Schlieker
Yale University · Department of Molecular Biophysics & Biochemistry
View Abstract

SFB 1551 Seminar Series Event - Axel Methner
2024-08-29 10:30 - 11:30 UTC
Talk announcement for Axel Methner

SFB 1551 Research Data Management Workshop 2024 - session A
2024-08-30 09:00 - 12:00 UTC | Biocenter 1 – Johannes Gutenberg University, Hanns-Dieter-Hüsch-Weg 15, Mainz, Rhineland-Palatinate, 55128, Germany

SFB 1551 Seminar Series Event - Prof. Dr. Andrea Musacchio
2024-09-02 14:00 - 17:00 UTC
1st talk at 14:00: “Feedback control of mitosis in the context of the kinetochore”
2nd talk at 15:30: “On the role of liquid-liquid phase separation in the establishment of biomolecular condensates”

By Prof. Dr. Andrea Musacchio
Max Plank Institute of Molecular Physiology Dortmund · Department of Mechanistic Cell Biology

SFB 1551 Research Data Management Workshop of image data 2024
2024-09-03 14:00 - 16:00 UTC | Biocenter 1 – Johannes Gutenberg University, Hanns-Dieter-Hüsch-Weg 15, Mainz, Rhineland-Palatinate, 55128, Germany

SFB 1551 Seminar Series Event - Dirk Schneider & Nadja Hellmann
2024-09-19 10:30 - 11:30 UTC
Isolating and characterizing proteins for in vitro condensate formation might be problematic!
Have you ever worked with isolated proteins? Most work in our group involves the isolation of (typically recombinantly produced) proteins plus their biophysical characterization. During this work, we encountered several problems associated with the insolation of tagged proteins and/or with their biophysical characterization. We have therefore decided to discuss some problems that typically occur but are often ignored “hands on”. We will focus on the isolation of tagged proteins plus their characterization via CD spectroscopy and/or dynamic light scattering. We will use examples from our own research with a condensate-forming protein to highlight some problems and pitfalls.

Liquid Matter Conference 2024
2024-09-22 08:00 - 2024-09-27 17:00 (Europe/Amsterdam) | Alte Mensa, Johann-Joachim-Becher-Weg 3-5, Mainz, 55128, Germany
This conference is organized by the Liquids Section of the Condensed Matter Division of the European Physical Society.
The aim of the conference is to bring together scientists working on the liquid state of matter. This rapidly growing field includes the physics, chemistry, biology, and chemical engineering of liquid matter as well as various applied research areas in the chemical, pharmaceutical and food industries.
The conference will consist of plenary lectures, topical symposia with keynote lectures and contributed oral presentations, and poster sessions. The plenary and keynote lectures will be streamed. All speakers will be on site.
More information (including topics, invited speakers, registration fees, etc.) can be found on the event website here.
(The above information was found on this page.)

SFB 1551 Student Seminar Series Event - Katrin Debrich & Mahesh Yadav
2024-09-24 12:30 - 13:30 UTC | Biocenter 2, Hanns-Dieter-Hüsch-Weg 17, Mainz
Phase separation of IM30, a protein involved in membrane dynamics by Katrin Debrich

Advancing the characterization of intrinsically disordered proteins by Mahesh Yadav

SFB 1551 Seminar Series Event - Katja Luck
2024-10-10 10:30 - 11:30 UTC
Talk announcement for Katja Luck

SFB 1551 Research Data Management Workshop 2024 - session B
2024-10-17 09:00 - 12:00 UTC | Biocenter 1 – Johannes Gutenberg University, Hanns-Dieter-Hüsch-Weg 15, Mainz, Rhineland-Palatinate, 55128, Germany

SFB 1551 Quantitative Microscopy for Biopolymers Workshop 2024
2024-10-21 - 2024-10-25 | Microscopy & Histology Core Facility (MHCF) – IMB, Ackermannweg 4, Mainz, 55128, Germany

SFB 1551 Student Seminar Series Event - Samuel Shoup & Lucia Baltz
2024-10-22 12:30 - 13:30 UTC | Biocenter 2, Hanns-Dieter-Hüsch-Weg 17, Mainz
Talk annoucement for Samuel Shoup & Lucia Baltz

SFB 1551 Annual Retreat 2024
2024-11-04 08:30 - 2024-11-05 16:30 UTC | Gonsberg Lounge, Im Niedergarten 16, Mainz, 55124, Germany

SFB 1551 Seminar Series Event - Prof. Dr. Wolfgang Binder
2024-11-14 10:30 - 11:30 UTC
Modulating aggregation & folding: photoswitchable amyloids & designed nano-compartimentized single chain nanoparticles
By Prof. Dr. Wolfgang Binder
Martin Luther University Halle-Wittenberg · Macromolecular Chemistry

SFB 1551 Student Seminar Series Event - Adrian Pinto
2024-11-19 12:30 - 13:30 UTC | Biocenter 2, Hanns-Dieter-Hüsch-Weg 17, Mainz
A coarse-grained model for SMC mediated loop extrusion.

Joint SFB 1551 & GRK2516 Seminar - Prof. Dr. Ir. Jurriaan Huskens
2024-11-28 10:30 - 11:30 UTC
Multivalent Interactions: from bio-inspiration to bio-application
By Prof. Dr. Ir. Jurriaan Huskens
University of Twente · Department for Molecules & Materials

SFB 1551 Seminar Series Event - René Ketting
2024-12-05 10:30 - 11:30 UTC | Biocenter I, EG 00.187, Hanns-Dieter-Hüsch-Weg 15, Mainz
Talk announcement for René Ketting.

SFB 1551 Seminar Series Event - Helle Ulrich
2024-12-12 10:30 - 11:30 UTC | Biocenter I, EG 00.187, Hanns-Dieter-Hüsch-Weg 15, Mainz
Getting to know the ubiquitin family – analysis & manipulation
Posttranslational modifications of proteins play essential regulatory roles in cells as they modulate their targets’ interactions, localization, and stability. This is achieved either by changing the biophysical properties of the targets or by providing interaction surfaces for dedicated receptors that elicit a biological signal. In this lecture, I will give a brief overview over the family of ubiquitin-like modifiers, their biochemical and biological properties, their enzymatic machinery, and their signalling functions in the cell. I will also cover established and innovative techniques to analyse and manipulate their activities in cells.

SFB 1551 Seminar Series Event - Julian König
2025-01-23 10:30 - 11:30 UTC
RNA Technologies
Thema: SFB1551 Seminar Series – Methods talk by Julian König
Zeit: 23.Jan. 2025 10:30 AM Amsterdam, Berlin, Rom, Stockholm, Wien
An Zoom-Meeting teilnehmen
https://uni-mainz-de.zoom.us/j/66599643238
Meeting-ID: 665 9964 3238

SFB 1551 Seminar Series Event - Dr. Sam Wilken
2025-02-13 10:30 - 11:30 UTC
Quantifying biophysical phenomena: image analysis techniques for fluorescent microscopy
By Dr. Sam Wilken
University of California, Santa Barbara, USA
