SFB 1551

SFB 1551 Research Data Management Workshop 2024 - session A
2024-08-30 09:00 - 12:00 UTC | Biocenter 1 – Johannes Gutenberg University, Hanns-Dieter-Hüsch-Weg 15, Mainz, Rhineland-Palatinate, 55128, Germany
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SFB 1551 Seminar Series Event - Axel Methner
2024-08-29 10:30 - 11:30 UTC
Talk announcement for Axel Methner

SFB 1551 Seminar Series Event - Prof. Dr. Christian Schlieker
2024-07-08 11:00 - 12:00 UTC
“(Dis)connecting Aberrant Nuclear Condensates and Neurological Disorders”
By Prof. Dr. Christian Schlieker
Yale University · Department of Molecular Biophysics & Biochemistry
View Abstract

SFB 1551 Seminar Series Event - Dr. Tanja Mittag & Prof. Kresten Lindorff-Larsen
2024-07-01 09:00 - 12:00 UTC
“Driving forces for phase separation, material properties and aging processes of condensates”
By Dr. Tanja Mittag
St. Jude Children’s Research Hospital · Department of Structural Biology
View abstract
“Towards structure prediction and design of disordered proteins”
By Prof. Dr. Kresten Lindorff-Larsen
Linderstrøm-Lang Centre for Protein Science · Structural Biology and NMR Laboratory
View abstract

SFB 1551 Seminar Series Event - Prof. Dr. Matthias Ballauff
2024-06-20 10:30 - 11:30 UTC
“Polyelectrolytes and Biological Systems: A Charged Relationship”
By Prof. Dr. Matthias Ballauff
Freie Universität Berlin · Institut für Chemie und Biochemie
View Abstract

Workshop with Prof. Heather Hofmeister (Joint Event with GenEvo, 4R, SFB1361, and SFB1551)
2024-06-06 09:30 - 13:00 UTC | IMB Seminar Room, Ackermannweg 4, Mainz, 55128, Germany
We are pleased to invite you to participate in a workshop with Prof. Heather Hofmeister entitled “Communication competencies in intercultural and intergenerational teams”.
This half-day workshop will focus on how to navigate conversations and differences in understanding each other based on different gender, cultural backgrounds, and expectations and locations in the power hierarchy and will be specifically designed for PhD students & early postdoctoral researchers from 4R, GenEvo, SFB 1361, and SFB 1551.
The workshop will be held on Thursday, June 6th, from 9:30 to 13:00, please mark your calendars!

EMBO | EMBL Symposium: Cellular mechanisms driven by phase separation
2024-05-14 08:00 - 2024-05-17 17:00 UTC | EMBL, Meyerhofstraße 1, Heidelberg, 69117
This conference will take place at EMBL Heidelberg, with the option to attend virtually.
Registration is now open! Click the link below to register for on-site or virtual attendance!
Symposium overview
Phase separation is emerging as a common biophysical basis underlying many important cellular functions. This conference will bring together scientists from soft matter, polymer physics, molecular biology, structural biology, and cell and developmental biology to study condensates in biology and disease. Goals are

to increase the awareness how important phase separation is for our understanding of many biological processes
to explore the large repertoire of new tools generated by other disciplines that are ripe to be applied to complex problems related to phase separation
to close the gap in transdisciplinary training to tackle the role of phase separation in biology

For more information please visit https://www.embl.org/about/info/course-and-conference-office/events/ees24-06/#vf-tabs__section-overview

SFB 1551 Seminar Series Event - Sina Wittmann
2024-05-02 10:30 - 11:30 UTC
Talk announcement for Sina Wittmann
Title: Protein condensation in the presence of nucleic acids
In the cell, many protein condensates form by nucleic acid binding proteins. This is true in the cytoplasm as well as in the nucleus. An example of the former would be RNA-binding proteins forming stress granules and of the latter the nucleolus. However, different physical phenomena can be behind these interactions. I will discuss different approaches of how to observe them experimentally.

SFB 1551 Seminar Series Event - Prof. Dr. Tassula Proikas-Cezanne
2024-04-25 10:30 - 11:30 UTC
Talk announcement for Prof. Dr. Tassula Proikas-Cezanne.

A role for WIPI beta propellers in autophagy and neurodegeneration
By Prof. Dr. Tassula Proikas-Cezanne
Eberhard Karls University Tübingen · Interfaculty Institute of Cell Biology (IFIZ)

SFB 1551 Seminar Series Event - Prof. Dr. Jörg Höhfeld
2024-04-11 10:30 - 11:30 UTC
Talk announcement for Prof. Dr. Jörg Höhfeld.

Maintaining the proteome under mechanical stress – from mechanisms to pathology
By Prof. Dr. Jörg Höhfeld
Universität Bonn · Institut für Zellbiologie
Abstract from Prof. Höhfeld:
Organismal survival depends on the ability to maintain functional protein networks even under conditions that threaten protein integrity. Cells in multicellular organisms are constantly exposed to stress resulting from mechanical forces. In this situation, protein homeostasis relies on a chaperone machinery that is organized by the co-chaperone BAG3. The BAG3-machinery recognizes force-unfolded cytoskeleton proteins and mediates their disposal through chaperone-assisted selective autophagy (CASA). In addition, BAG3 interacts with components of the Hippo and mTOR signalling pathways to stimulate transcription and translation. This is important for compensating degradation during cytoskeleton maintenance. In agreement with its essential role under mechanical stress, BAG3 deficiency causes severe muscle weakness in children and contributes to heart failure, a leading cause of mortality in industrialized nations. Here, we discuss the mode of action of the BAG3-machinery and its force-dependent regulation and pathophysiological relevance.

SFB 1551 Seminar Series Event - Prof. Dr. Ralf Metzler
2024-03-14 10:30 - 11:30 UTC
Talk announcement for Prof. Dr. Ralf Metzler.

“Long-ranged correlated processes in disordered systems”
By Prof. Dr. Ralf Metzler
Universität Potsdam
Abstract from Prof. Metzler:
Stochastic processes with long-ranged, power-law correlations naturally emerge in systems such as Rouse polymers or single-file systems, when all degrees of freedom are integrated out, apart from the (tracer) particle of interest. In non-equilibrium situations, the resulting overdamped dynamics corresponds to Mandelbrot’s fractional Brownian motion (FBM).
This talk will address some peculiar behaviours of FBM when subject to confinement in box potentials as well as sub- or superharmonic external potentials. Specifically, it will be argued why superdiffusive FBM may be a good (polymer) model for growing serotonergic fibres in the mammalian brain.
In disordered environments it will be shown how non-Gaussian displacement density functions emerge and subtly depend on how the dynamics is introduced. This is achieved by stochastic-diffusivity models connected with long-range dependent noise. Moreover, it will be discussed how time-dependent critical exponents can be introduced in this formalism.
Finally, amoeba systems will be introduced in which the displacement density function appears to converge to a non-Gaussian, Laplace density.

SFB1551 Winter School
2024-03-04 09:00 - 2024-03-07 17:00 UTC | Kurpark-Hotel, Schloßplatz 1-4, Bad Dürkheim, 67098, Germany

SFB 1551 Seminar Series Event - Prof. Dr. Konstanze Winklhofer
2024-02-22 10:30 - 11:30 UTC
Talk announcement for Prof. Dr. Konstanze Winklhofer

“Linear polyubiquitin as a regulator of phase transitions in signaling and protein quality control”
By Prof. Dr. Konstanze Winklhofer
Ruhr-Universität Bochum

SFB 1551 Seminar Series Event - Prof. Dr. Andela Saric
2024-02-06 10:30 - 11:30 UTC
Talk announcement for Prof. Dr. Andela Saric.

“Protein assemblies that split and merge cells across evolution”
By Prof. Dr. Andela Saric
Institute of Science and Technology Austria
Abstract from Prof. Saric:
I will present our recent research on the computational modelling of energy-consuming protein filaments that dynamically reshape and cut cells across evolution. I will first discuss the physical mechanism of ESCRT-III filaments that drive cell division and cell trafficking in archaea and eukaryotes. I will then discuss the physical mechanism behind the dynamic self-organisation of biochemically active FtsZ filaments in the early stages of bacterial division. Throughout, I will present the comparisons of our models to in vitro and in vivo data. I will finish up with our recent thoughts on the shapes of symbiotic organisms that might have led to the emergence of eukaryotes.

Workshop with Prof. Heather Hofmeister (Joint Event with GenEvo, 4R, SFB1361, and SFB1551)
2024-02-01 15:30 - 19:30 UTC
We are pleased to invite you to participate in a workshop with Prof. Heather Hofmeister entitled “Navigating challenging conversations within power hierarchies”.
This half-day workshop will focus on how to navigate “difficult” conversations and differences in understanding each other based on different gender, cultural backgrounds, and expectations and locations in the power hierarchy and will be specifically designed for PhD students & early postdoctoral researchers from 4R, GenEvo, SFB 1361, and SFB 1551.
The workshop will be held on Thursday, February 1st, from 15:30 to 19:00, followed by a pizza dinner. Please mark your calendars! Official registration for the workshop will follow in January. Participation will be credited with 2 hours (towards your IPP certificate).
To ensure that the workshop also addresses any more specific questions or requests, please feel free to share them with us in advance using this link (anonymous).

SFB 1551 Seminar Series Event - Dorothee Dormann
2024-01-11 09:00 - 11:00 UTC
Talk announcement for Dorothee Dormann.

Experimental methods to study aggregation-prone RNA-binding proteins (part 2)

SFB 1551 Seminar Series Event - Prof. Dr. Christoph Weber
2023-12-14 11:00 - 12:00 (Europe/Amsterdam)
Talk announcement for Prof. Dr. Christoph Weber.

Christmas Colloquium (Jointly organised by SFB1361, SFB1551, GenEvo, 4R-RTG)
2023-12-13 16:00 UTC | IMB Seminar Room, Ackermannweg 4, Mainz, 55128, Germany
We are delighted to invite you all to a Christmas Colloquium on Wednesday, 13 December 2023 starting at 16:00, and followed by dinner and merriment! This is a joint event organised by SFB 1361, SFB 1551, GenEvo, and 4R-RTG.

There will be an interesting talk given by a 2023 Alexander von Humboldt Professorship recipient, Prof. Hanna Kokko. She is a theoretical evolutionary biologist and is currently based in JGU carrying out research to better understand the interaction between evolutionary and ecological processes.

The event is open to all members of the SFB 1361, SFB 1551, GenEvo, and 4R-RTG. So, mark your calendars and come join us in the IMB seminar room for the talk and get-together afterwards!

Postponed - SFB 1551 Seminar Series Event - Prof. Dr. Tassula Proikas-Cezanne
2023-12-07 10:30 - 11:30 UTC

SFB 1551 Seminar Series Event - Dr. Emanuele Buratti
2023-11-09 10:30 - 12:00 UTC
Talk announcement for Dr. Emanuele Buratti

Axon guidance genes are regulated by ALS associated TDP-43 and RGNEF genes through the rate of long-intron processing
By Dr. Emanuele Buratti
International Centre for Genetic Engineering and Biotechnology

SFB 1551 Seminar Series Event - Dorothee Dormann
2023-10-12 09:00 - 11:00 UTC
Talk announcement for Dorothee Dormann

SFB 1551 Annual Retreat
2023-10-04 09:00 - 2023-10-06 18:00 UTC | Kloster Höchst, Kirchberg 3, Höchst im Odenwald, 64739, Germany

SFB 1551 Workshop - Science & Communication
2023-10-02 09:00 - 11:30 UTC
We are having a Science & Communication workshop on October 2, 2023.
Talks included in this workshop:
“Natural Product research: a journey back to the future”
“The heart is the central organ of the body, but what about science?”
“Investigating New Drug Options for Temozolomide-Resistant IDH1 Mutant Glioma”
“Hydrogen’s Horizons: Harnessing Nature’s Hints and Novel Notions”

SPP 2191 annual meeting 2023
2023-09-24 08:00 - 2023-09-28 17:00 UTC
Save the dates for our upcoming annual meeting in Dresden.
September 24 – 28, 2023

More info on location, registration and program will follow soon!

SFB 1551 Seminar Series Event - Svenja Morsbach
2023-09-14 09:00 - 11:00 UTC | Biocenter I, EG 00.187, Hanns-Dieter-Hüsch-Weg 15, Mainz
Talk announcement for Svenja Morsbach

SFB 1551 Seminar Series Event - Martin Girard
2023-08-24 09:00 - 11:00 UTC | Biocenter I, EG 00.187, Hanns-Dieter-Hüsch-Weg 15, Mainz
Talk announcement of Martin Girard
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*From lead to cells: digital alchemy, multicomponent mixtures, and chemical regulation*
by Dr. Martin Girard
Max-Planck-Institute for Polymer Research

Public Outreach Event: Verjüngung ist möglich. Die neuesten Erkenntnisse der Zellbiologie
2023-06-27 18:00 - 19:30 UTC | Institute of Molecular Biology, Ackermannweg 4, Mainz
Öffentlicher Vortrag von Nina Ruge
Nina Ruge / Prof. Dr. Dorothee Dormann (SFB 1551, IMB/Johannes Gutenberg-Universität Mainz) / Prof. Dr. Peter Baumann (IMB/Johannes Gutenberg-Universität Mainz) / Clemens Hoch (Minister für Wissenschaft und Gesundheit des Landes Rheinland-Pfalz) / Moderation: Christof Niehrs (Gründungsdirektor und wissenschaftlicher Direktor, IMB).
Wir laden Sie am Dienstag, 27. Juni um 18:00 Uhr herzlich an das Institut für Molekulare Biologie (IMB) in Mainz ein, wenn Nina Ruge sich in ihrem Vortrag „Verjüngung ist möglich. Die neuesten Erkenntnisse der Zellbiologie“ damit auseinandersetzt, was wir heute schon – wissenschaftlich fundiert – für ein gesundes Altern tun können.
Nina Ruge ist bekannt aus Formaten wie dem „heute journal“, „heute Nacht“ und „Leute heute“ im ZDF, und moderierte zahllose weitere Talkshows und TV-Magazine. Heute ist sie schwerpunktmäßig als Autorin tätig, u.a. als Fachautorin für die ‚Zellbiologie des Alterns‘. Ihre beiden Bücher, „Altern wird heilbar. Jung bleiben mit der Kraft der drei Zellkompetenzen“ (2020) und „Verjüngung ist möglich. Wissenschaftlich erforscht – was wirklich hilft“ (2021), entführen die Leser:innen in die spannende Welt der modernen Forschung zum Altern und zu „Longevity“.
Im Anschluss an ihren Vortrag wird Frau Ruge mit den beiden Mainzer Forschenden Prof. Dr. Dorothee Dormann (SFB 1551 IMB/Johannes Gutenberg-Universität Mainz) und Prof. Dr. Peter Baumann (IMB/Johannes Gutenberg-Universität Mainz) und Minister Clemens Hoch (Minister für Wissenschaft und Gesundheit des Landes Rheinland-Pfalz) neueste Erkenntnisse der Alternsforschung und deren Bedeutung diskutieren. Moderiert wird die Veranstaltung von Prof. Dr. Christof Niehrs (Gründungsdirektor und wissenschaftlicher Direktor, IMB).
Die Veranstaltung ist eine Kooperation des Instituts für Molekulare Biologie (IMB) und des Centre for Healthy Ageing (CHA) in Mainz und wird unterstützt vom SFB 1361.
Vortrag und Diskussion werden auf Deutsch gehalten und richten sich an ein breites Publikum.
Die Besucheranzahl ist begrenzt, wir bitten daher um verbindliche Anmeldung bis zum 16. Juni hier

Joint SFB 1551 & TRR 146 Seminar Series Event - Abhishek Singharoy
2023-06-21 14:30 - 16:00 UTC | Minkowski Room, Staudingerweg 7, Mainz, Germany
Talk announcement of Abhishek Singharoy

*Biophysics at the Dawn of Exascale Computers – The Age of Molecular Simulation Bots*
Abstract:
Molecular modeling of biomolecular assemblies exemplifies a disruptive area holding both promises and contentions. We will start with a brief story of simulating the first ever cell organelle in molecular details to find how nature has chosen survival fitness over efficiency of energy transfer as an evolutionary design . Despite such advances in exascale computing, biophysical simulation continues to grapple with handling molecular diversity. So, we will employ deep learning approaches often used in Google searches, called the inception network, to marry interaction signatures from alphafold models and proteomics analysis with predictable patient outcomes. An application will highlight how molecular modeling is used at an industrial scale to de-risk vector-based vaccines for distribution across 194 countries. We will conclude by seeing how transient interactions are difficult to predict, and path integrals with reinforcement learning offer a possible way to track diversity of dynamics.
by Assistant Prof. Abhishek Singharoy
Arizona State University
School of Molecular Sciences

Joint SFB 1551 & SFB 1361 Seminar Series Event - Matthias Altmeyer
2023-06-16 10:00 - 11:00 UTC | Seminar room 2nd floor, Ackermannweg 4, Mainz, Germany
Talk announcement of Matthias Altmeyer

*Dynamics and Functions of DNA Repair Compartments*
Abstract:
Genome stability is constantly challenged by reactive byproducts of
cellular metabolism and environmental toxins. Dedicated repair pathways
have evolved to deal with DNA damage, and their malfunctioning is
associated with human diseases such as cancer and neurodegeneration.
Elucidation of the hierarchy and temporal order in which DNA damagesensing
proteins as well as signaling and repair factors assemble around
DNA lesions has painted a complex picture of tightly regulated
macromolecular interactions that build specialized nuclear compartments
to facilitate repair and maintain genome integrity. While many of the
underlying interactions, e.g. between repair factors and damage-induced
histone modifications, can be explained by lock-and-key or induced fit
binding models assuming fixed stoichiometries, structurally less well
defined interactions, such as the highly dynamic multivalent interactions
implicated in biomolecular condensate formation by phase separation,
also participate in the formation of multi-protein assemblies at sites of
DNA damage. In this seminar, a summary and an update will be provided
on efforts to characterize and better understand the dynamics and
functions of cellular DNA repair compartments and how they coordinate
maintenance of genome integrity in space and time.

by Prof. Dr. Matthias Altmeyer
University of Zurich
Department of Molecular Mechanisms of Disease

Talk_Announcement_Altmeyer

Gutenberg Workshop - Multivalent Interactions in Aging – Targets for Intervention?
2023-05-03 09:00 - 2023-05-05 13:30 UTC | Kloster Wasem, Edelgasse 15, Ingelheim, Germany
This workshop will bring together experts in molecular aging, biopolymer interactions and polymer theory to discuss how non-deterministic, multivalent and disordered biomolecular interactions contribute to cellular function. While multivalent interactions come with a certain degree of resilience to perturbation, it is well known that disturbances of such interactions contribute to aging and devastating degenerative diseases. At this workshop, participants will discuss our current understanding of non-deterministic assemblies driven by disorder and multivalency and possible pathways towards the design of new and innovative intervention strategies to treat age-associated diseases.

Confirmed Speakers:
Simon Alberti, TU Dresden (GER)
Thomas Boothby, University of Wyoming (USA)
Alexander Buell, DTU (Denmark)
Della David, Babraham (UK)
Lin Guo, Thomas Jefferson University (USA)
Martin Hetzer, ISTA (Austria)
Tuomas Knowles, University of Cambridge (UK)
Chiu Fan Lee, Imperial College (UK)
Sua Myong, Johns Hopkins (USA)
Rohit Pappu, Washington University in St Louis (USA)
Kausik Si, Stowers Institute (USA)
Liesbeth Veenhoff, ERIBA (Netherlands)
Susanne Wegmann, DZNE (GER)
Scientific Organizers: Dorothee Dormann and Edward Lemke
