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X-WR-CALDESC:Events for SFB 1551
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DTSTART;TZID=UTC:20251204T103000
DTEND;TZID=UTC:20251204T113000
DTSTAMP:20251203T124439Z
CREATED:20250313T135921Z
LAST-MODIFIED:20251203T124439Z
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SUMMARY:SFB 1551 Seminar Series Event - Prof. Dr. Pol Besenius
DESCRIPTION:Methods talk by Prof. Dr. Pol Besenius\, Chemistry Department\, Johannes Gutenberg University \nWeak Non-Covalent Interactions in Biopolymer and Synthetic Supramolecular Assemblies \nThis lecture introduces the basic principles that define modern supramolecular chemistry through a historical and conceptual overview of non-covalent interactions. We will examine the nomenclature and evolution of key interaction types\, including hydrogen bonding\, Coulomb interactions\, π–π stacking and related interactions in aromatic systems. Emphasis will be placed on understanding how enthalpic and entropic contributions govern the formation\, strength\, and selectivity of supramolecular assemblies. Finally\, we will explore the crucial role of the solvent environment—highlighting solvation and solvophobic effects in (macro)molecular recognition and self-assembly. These elements provide a framework for analyzing and designing non-covalent systems across chemistry\, biology\, and materials science.
URL:https://crc1551.com/our-event/sfb-1551-seminar-series-event-prof-dr-pol-besenius/
LOCATION:Biocenter I\, EG 00.187\, Hanns-Dieter-Hüsch-Weg 15\, Mainz
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DTSTART;TZID=UTC:20251205T090000
DTEND;TZID=UTC:20251205T100000
DTSTAMP:20251124T095029Z
CREATED:20251124T095029Z
LAST-MODIFIED:20251124T095029Z
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SUMMARY:SFB 1551 Seminar Series Event - Dr. Sergio Cruz-Leon
DESCRIPTION:“Bridging cellular 3D imaging with physics-based simulations for biological discovery” \nDr. Sergio Cruz-Leon (MPI Biophysics\, Frankfurt) \nSummary: \nCellular function is governed by the structure\, location\, and dynamics of its densely packed molecular machines. Cryo-electron tomography (cryoET) captures 3D snapshots of intact cells at near molecular resolution. However\, extracting reliable molecular identities and interactions from tomographic data remains challenging. \nI will show how high-confidence 3D template matching (hcTM) for cryoET [1]\, coupled with multiscaling\, enables us to model and simulate biological landscapes directly from cryoET data [1-3]. hcTM reliably localizes a wide range of macromolecular complexes in crowded cytoplasm and nuclei\, producing spatial maps that are the basis to build simulation-ready models of subcellular environments. \nUsing this framework\, we uncovered vault particles loaded with ribosomal cargo [1] and the unexpected ‘cracking’ of the nuclear pore complex (NPC) during HIV passage [2]\, and resolved the molecular architecture of human chromatin in situ [3]. We then applied it to an autophagy-related condensate directly in cells\, demonstrating that a single amino-acid substitution strengthens intermolecular interactions\, drives a liquid-to-glass mesoscale transition\, and abolishes autophagic clearance. We thereby link a molecular alteration to changes in condensate material properties and biological function. \nIntegrating in situ imaging with multiscale simulation provides a pipeline for visual proteomics and sets the stage for simulating cellular processes in their native context. \n  \nKeywords: Visual proteomics\, cryoET\, high-confidence template matching\, multi-scale simulations\, HIV\, chromatin\, biomolecular condensates. \n  \n[1] Cruz-León\, et al.\, Nat. Comm.\, 2024 \n[2] Kreysing*\, Heidari*\, Zila*\, et al.\, Cell\, 2025 \n[3] Kreysing*\, Cruz-León*\, Betz*\, et al.\, BioRxiv\, 2025
URL:https://crc1551.com/our-event/sfb-1551-seminar-series-event-dr-sergio-cruz-leon/
LOCATION:BZ2 Room 02.721 (2nd floor)\, Hans-Dieter-Hüsch-Weg 17\, Mainz\, Germany
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