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TZID:UTC
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DTSTART:20220101T000000
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DTSTART;TZID=UTC:20260813T100000
DTEND;TZID=UTC:20260813T180000
DTSTAMP:20260401T133131Z
CREATED:20260401T133131Z
LAST-MODIFIED:20260401T133131Z
UID:10000115-1786615200-1786644000@crc1551.com
SUMMARY:SFB1551 3rd Rehearsal - Network internal event
DESCRIPTION:This is a closed event for SFB1551 members only
URL:https://crc1551.com/our-event/sfb1551-3rd-rehearsal-network-internal-event/
LOCATION:Biocenter I\, EG 00.187\, Hanns-Dieter-Hüsch-Weg 15\, Mainz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20260618T100000
DTEND;TZID=UTC:20260618T180000
DTSTAMP:20260401T133018Z
CREATED:20260401T133018Z
LAST-MODIFIED:20260401T133018Z
UID:10000114-1781776800-1781805600@crc1551.com
SUMMARY:SFB1551 2nd Rehearsal - Network internal event
DESCRIPTION:This is a closed event for SFB1551 members only
URL:https://crc1551.com/our-event/sfb1551-2nd-rehearsal-network-internal-event/
LOCATION:Biocenter I\, EG 00.187\, Hanns-Dieter-Hüsch-Weg 15\, Mainz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Amsterdam:20260507T090000
DTEND;TZID=Europe/Amsterdam:20260507T094500
DTSTAMP:20260415T130636Z
CREATED:20260413T132852Z
LAST-MODIFIED:20260415T130636Z
UID:10000123-1778144400-1778147100@crc1551.com
SUMMARY:Expert Talk - Your Digital Lab Notebook for Simulations: Research Data Management with NOMAD Oasis
DESCRIPTION:by Dr. Hampus Näsström\, Technical Coordinator\, HU Berlin \nThis is a hybrid event. \nThis session introduces NOMAD Oasis as a platform for managing and documenting computational data in a structured and reproducible way. It covers the core functionalities from a user perspective\, including data organization\, metadata handling\, and integration into calculation workflows. \nThe focus is on practical approaches to documenting dry-lab research\, enabling traceability\, reproducibility\, and efficient collaboration across projects. \nThe talk provides a practical entry point into using digital tools for calculation-focused research data management and supports participants in structuring their own workflows accordingly.
URL:https://crc1551.com/our-event/sfb1551-rdm-week-2026-expert-talk-your-digital-lab-notebook-for-simulations-research-data-management-with-nomad-oasis/
LOCATION:Biocenter I\, EG 00.187\, Hanns-Dieter-Hüsch-Weg 15\, Mainz
CATEGORIES:RDM
ATTACH;FMTTYPE=image/jpeg:https://crc1551.com/wp-content/uploads/2026/04/RDM-Week-2026-cover-page.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Amsterdam:20260506T090000
DTEND;TZID=Europe/Amsterdam:20260506T094500
DTSTAMP:20260415T130617Z
CREATED:20260413T132840Z
LAST-MODIFIED:20260415T130617Z
UID:10000122-1778058000-1778060700@crc1551.com
SUMMARY:Expert Talk - Your Lab Notebook Reinvented: Research Documentation with eLabFTW
DESCRIPTION:by Dr. Lukas Hellmann\, Systemadmin eLabFTW\, JGU \nThis is a hybrid event. \nThis session introduces eLabFTW as an electronic lab notebook for structured and efficient research documentation. It covers the core functionalities from a user perspective\, including experiment documentation\, data organization\, and collaboration features. \nThe talk provides a clear entry point into digital lab notebook usage. The focus is on practical workflows that support consistent and transparent documentation in everyday lab work\, with minimal additional overhead.
URL:https://crc1551.com/our-event/sfb1551-rdm-week-2026-expert-talk-your-lab-notebook-reinvented-research-documentation-with-elabftw/
LOCATION:Biocenter I\, EG 00.187\, Hanns-Dieter-Hüsch-Weg 15\, Mainz
CATEGORIES:RDM
ATTACH;FMTTYPE=image/jpeg:https://crc1551.com/wp-content/uploads/2026/04/RDM-Week-2026-cover-page.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Amsterdam:20260504T090000
DTEND;TZID=Europe/Amsterdam:20260504T094500
DTSTAMP:20260415T130522Z
CREATED:20260413T132552Z
LAST-MODIFIED:20260415T130522Z
UID:10000120-1777885200-1777887900@crc1551.com
SUMMARY:Expert Talk - Don't Lose Your Data: Backup Strategies and Encryption for the Research Lab
DESCRIPTION:by Dr. Andrej Berg\, Data Steward\, JGU \nThis is a hybrid event. \nThis session introduces practical strategies for safeguarding research data in everyday workflows. It covers structured backup approaches and the fundamentals of encryption to ensure data integrity and security. The focus is on solutions that can be implemented with minimal overhead in both experimental and computational settings. \nThe talk provides a clear foundation for developing robust data protection practices and prepares participants to apply these concepts directly in their everyday work.
URL:https://crc1551.com/our-event/sfb1551-rdm-week-2026-expert-talk-dont-lose-your-data-backup-strategies-and-encryption-for-the-research-lab/
LOCATION:Biocenter I\, EG 00.187\, Hanns-Dieter-Hüsch-Weg 15\, Mainz
CATEGORIES:RDM
ATTACH;FMTTYPE=image/jpeg:https://crc1551.com/wp-content/uploads/2026/04/RDM-Week-2026-cover-page.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20260413T120000
DTEND;TZID=UTC:20260413T180000
DTSTAMP:20260401T120912Z
CREATED:20260401T120803Z
LAST-MODIFIED:20260401T120912Z
UID:10000113-1776081600-1776103200@crc1551.com
SUMMARY:SFB1551 1st Rehearsal - Network internal event
DESCRIPTION:This is closed event for SFB1551 Group Leaders only
URL:https://crc1551.com/our-event/sfb1551-1st-rehearsal-network-internal-event/
LOCATION:Biocenter I\, EG 00.187\, Hanns-Dieter-Hüsch-Weg 15\, Mainz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20260122T103000
DTEND;TZID=UTC:20260122T113000
DTSTAMP:20260114T102219Z
CREATED:20260114T094637Z
LAST-MODIFIED:20260114T102219Z
UID:10000109-1769077800-1769081400@crc1551.com
SUMMARY:SFB 1551 Seminar Series Event - Dr. Davide Mercadante
DESCRIPTION:“Functional advantages of protein structural disorder as revealed by integrative biophysics” \nDr. Davide Mercadante (School of Chemical Sciences\, The University of Auckland\, Auckland\, New Zealand) \nSummary:\nSince the discovery that protein structural disorder holds functional relevance intrinsically disordered proteins (IDPs) have become a cornerstone of biophysics.\nCharacterized by extremely high dynamics\, IDPs are elusive by nature and traditional structural biology techniques remain largely uncapable of providing an exhaustive understanding of their behavior.\nHowever\, the qualitative and quantitative integration of computational experimental techniques well-versed to assess protein dynamics\, thus provides a powerful framework to elucidate IDPs’ dynamics-driven functions. This talk will overview how the integration of biophysical approaches within the experimental and computational realms has favored the discovery of new functional paradigms empowered by protein disorder. 1–5 I will showcase how simulations employing all-atom or coarse-grained modelling of protein chains\, can help linking the conformational behavior of IDPs to their ensemble-based function: and how it can be possible to obtain experimentally sound protein ensembles from coarse grained protein models\, through a direct integration of NMR observables into simulations. 6\,7 \nReferences\n1. Milles\, S. et al. Plasticity of an Ultrafast Interaction between Nucleoporins and Nuclear Transport Receptors. Cell 163\, 734–745 (2015).\n2. Swain\, B. C. et al. Disordered regions of human eIF4B orchestrate a dynamic self-association landscape. Nat Commun 15\, 8766 (2024).\n3. Heidarsson\, P. O. et al. Release of linker histone from the nucleosome driven by polyelectrolyte competition with a disordered protein. Nat Chem 14\, 224–231 (2022).\n4. Bjarnason\, S. et al. DNA binding redistributes activation domain ensemble and accessibility in pioneer factor Sox2. Nat Commun 15\, (2024).\n5. Buholzer\, K. J. et al. Multilayered allosteric modulation of coupled folding and binding by phosphorylation\, peptidyl-prolyl cis / trans isomerization\, and diversity of interaction partners. Journal of Chemical Physics 157\, (2022).\n6. Cullen\, M. et al. Integrating NMR restraints into coarse-grained simulations: toward accurate conformational ensembles of complex protein systems. bioRxiv 2025.12.22.695971 (2025) doi:10.64898/2025.12.22.695971.\n7. Cullen\, M. et al. Capturing secondary structure in coarse grained intrinsically disordered proteins with simulations driven by chemical shifts. bioRxiv 2026.01.06.697719 (2026) doi:10.64898/2026.01.06.697719.
URL:https://crc1551.com/our-event/sfb-1551-seminar-series-event-dr-davide-mercadante/
LOCATION:Biocenter I\, EG 00.187\, Hanns-Dieter-Hüsch-Weg 15\, Mainz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20251204T103000
DTEND;TZID=UTC:20251204T113000
DTSTAMP:20251203T124439Z
CREATED:20250313T135921Z
LAST-MODIFIED:20251203T124439Z
UID:10000099-1764844200-1764847800@crc1551.com
SUMMARY:SFB 1551 Seminar Series Event - Prof. Dr. Pol Besenius
DESCRIPTION:Methods talk by Prof. Dr. Pol Besenius\, Chemistry Department\, Johannes Gutenberg University \nWeak Non-Covalent Interactions in Biopolymer and Synthetic Supramolecular Assemblies \nThis lecture introduces the basic principles that define modern supramolecular chemistry through a historical and conceptual overview of non-covalent interactions. We will examine the nomenclature and evolution of key interaction types\, including hydrogen bonding\, Coulomb interactions\, π–π stacking and related interactions in aromatic systems. Emphasis will be placed on understanding how enthalpic and entropic contributions govern the formation\, strength\, and selectivity of supramolecular assemblies. Finally\, we will explore the crucial role of the solvent environment—highlighting solvation and solvophobic effects in (macro)molecular recognition and self-assembly. These elements provide a framework for analyzing and designing non-covalent systems across chemistry\, biology\, and materials science.
URL:https://crc1551.com/our-event/sfb-1551-seminar-series-event-prof-dr-pol-besenius/
LOCATION:Biocenter I\, EG 00.187\, Hanns-Dieter-Hüsch-Weg 15\, Mainz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20251120T143000
DTEND;TZID=UTC:20251120T153000
DTSTAMP:20251118T111640Z
CREATED:20250313T093024Z
LAST-MODIFIED:20251118T111640Z
UID:10000092-1763649000-1763652600@crc1551.com
SUMMARY:SFB 1551 Seminar Series Event - Prof. Dr. Andreas Walther
DESCRIPTION:Methods talk by Prof. Dr. Andreas Walther\, Chemistry Department\, Johannes Gutenberg University \nTitle: “DNA Nanoscience Tools  \nSummary: \nDNA is not just genetic information but allows for precision design of programmable matter. This lecture will give an overview of selected DNA Nanoscience principles to build complex structures\, switches\, reaction networks\, and\, if time\, some robots and machines. \nDate: 20.11.2025\nTime: 14:30 – 15:30\nLocation: BZ1 room HS 00.187
URL:https://crc1551.com/our-event/sfb-1551-seminar-series-event-prof-dr-andreas-walther/
LOCATION:Biocenter I\, EG 00.187\, Hanns-Dieter-Hüsch-Weg 15\, Mainz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20251023T103000
DTEND;TZID=UTC:20251023T113000
DTSTAMP:20251017T130455Z
CREATED:20250314T135838Z
LAST-MODIFIED:20251017T130455Z
UID:10000098-1761215400-1761219000@crc1551.com
SUMMARY:SFB 1551 Seminar Series Event - Prof. Dr. Petra Beli
DESCRIPTION:Methods talk by Prof. Dr. Petra Beli\, Institute of Molecular Biology (IMB) \nQuantitative proteomics for investigations of protein-protein interactions and phosphorylation \nIn this methods talk\, I will provide an overview of mass spectrometry based proteomics approaches for analyzing protein-protein interactions and posttranslational modifications. I will focus on new proximity-based methods for analyzing transient and low affinity interactions that are also applicable for the analysis of phase-separated membraneless compartments. In addition\, I will give an overview into the quantitative analysis of posttranslational interactions with a focus on global and targeted analysis of protein phosphorylation.
URL:https://crc1551.com/our-event/sfb-1551-seminar-series-event-prof-dr-petra-beli/
LOCATION:Biocenter I\, EG 00.187\, Hanns-Dieter-Hüsch-Weg 15\, Mainz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20251009T103000
DTEND;TZID=UTC:20251009T113000
DTSTAMP:20251008T081955Z
CREATED:20250314T135708Z
LAST-MODIFIED:20251008T081955Z
UID:10000097-1760005800-1760009400@crc1551.com
SUMMARY:SFB 1551 Seminar Series Event - Prof. Dr. Thomas Speck
DESCRIPTION:Methods talk by Prof. Dr. Thomas Speck\, Theoretical Physics Department\, Stuttgart University \nMore is different: Statistical physics of structure formation \nHow can we even dare to model complex phenomena like cellular processes in biology? I will introduce the philosophy of statistical physics to approach this question through minimal models and I will illustrate the key concepts for the case of phase separation. I will then sketch the current challenges of non-equilibrium and many-component systems and how we tackle those.
URL:https://crc1551.com/our-event/sfb-1551-seminar-series-event-prof-dr-thomas-speck/
LOCATION:Biocenter I\, EG 00.187\, Hanns-Dieter-Hüsch-Weg 15\, Mainz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20250904T103000
DTEND;TZID=UTC:20250904T113000
DTSTAMP:20250818T155427Z
CREATED:20250314T135513Z
LAST-MODIFIED:20250818T155427Z
UID:10000096-1756981800-1756985400@crc1551.com
SUMMARY:SFB 1551 Seminar Series Event - Dr. Ralf Dahm
DESCRIPTION:Methods talk by Dr. Ralf Dahm\, Institute of Molecular Biology (IMB) \nWhen Discovery Isn’t Enough: Why It Matters to Communicate Your Science Well \nImagine making a discovery that could change your field—only to watch it vanish into obscurity because no one quite “got it.” This happens more often than we’d like to admit. Breakthroughs don’t automatically break through; they need a voice\, be well presented\, and connect with the audience. Without these\, even the most insightful finding risks staying a hidden gem—brilliant\, but unseen. \nToday\, good science communication is not just a “nice-to-have” skill—it’s essential for building a successful career as a scientist. From publishing in high-impact journals and giving convincing talks to attracting collaborators and securing funding: being able to communicate well ensures that your work gets recognized. \nIn this talk\, I will explore key aspects of how to communicate research in ways that are clear\, compelling\, and memorable—whether to your peers\, collaborators from a different field\, or the public. We will look at how to turn complex concepts into ideas people can understand\, how to make your research resonate\, and how to deliver your message so it sticks. By the end\, you will have practical tools to help you communicate your research effectively.
URL:https://crc1551.com/our-event/sfb-1551-seminar-series-event-prof-dr-ralf-dahm/
LOCATION:Biocenter I\, EG 00.187\, Hanns-Dieter-Hüsch-Weg 15\, Mainz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20250821T103000
DTEND;TZID=UTC:20250821T113000
DTSTAMP:20250812T081607Z
CREATED:20231122T103722Z
LAST-MODIFIED:20250812T081607Z
UID:10000051-1755772200-1755775800@crc1551.com
SUMMARY:SFB 1551 Seminar Series Event - Prof. Dr. Tanja Weil
DESCRIPTION:Talk announcement for Tanja Weil.
URL:https://crc1551.com/our-event/sfb-1551-seminar-series-event-tanja-weil/
LOCATION:Biocenter I\, EG 00.187\, Hanns-Dieter-Hüsch-Weg 15\, Mainz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20250724T103000
DTEND;TZID=UTC:20250724T113000
DTSTAMP:20250626T160104Z
CREATED:20250314T135344Z
LAST-MODIFIED:20250626T160104Z
UID:10000095-1753353000-1753356600@crc1551.com
SUMMARY:SFB 1551 Seminar Series Event - Prof. Dr. Shikha Dhiman
DESCRIPTION:Methods talk by Prof. Dr. Shikha Dhiman\, Chemistry Department\, Johannes Gutenberg University \nHarnessing Competitive Interactions to Regulate Supramolecular Assembly \nAbstract:\nUnderstanding the interplay between supramolecular polymerization and phase separation is key to unraveling the formation of biomolecular assemblies such as protein fibers and membraneless organelles. I will present a minimal synthetic system—comprising a BTA-based monomer\, surfactant\, and water—that mimics biological condensates through a micelle-to-droplet-to-fiber transition. This pathway\, governed by competitive interactions\, is reversible under external stimuli like temperature and guest molecules. Our findings offer a framework for controlling supramolecular order and dynamics\, with implications for synthetic biology and therapeutic design.
URL:https://crc1551.com/our-event/sfb-1551-seminar-series-event-prof-dr-shikha-dhiman/
LOCATION:Biocenter I\, EG 00.187\, Hanns-Dieter-Hüsch-Weg 15\, Mainz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20250703T103000
DTEND;TZID=UTC:20250703T113000
DTSTAMP:20250626T155809Z
CREATED:20250313T093000Z
LAST-MODIFIED:20250626T155809Z
UID:10000094-1751538600-1751542200@crc1551.com
SUMMARY:SFB 1551 Seminar Series Event - Dr. Martin Möckel
DESCRIPTION:Methods talk by Dr. Martin Möckel\, Institute of Molecular Biology (IMB) \nIn vitro veritas – an overview on recombinant protein expression\, purification and quality control \nAbstract: \nRecombinant proteins are critical for basic research\, for example to prove molecular mechanisms\, determine protein structure and study the biophysical properties of proteins in a well-defined environment. In this talk I will give you a glimpse on the art of protein production as is done in our core facility. We will start by looking at molecular cloning techniques for expression vector generation\, as well as pros and cons of various expression systems\, with a focus on E. coli and the baculovirus-insect cell system. This will be followed by a more detailed explanation of various chromatography techniques\, before ending the talk with a short overview of possible quality control measurements. \n 
URL:https://crc1551.com/our-event/sfb-1551-seminar-series-event-dr-martin-mockel/
LOCATION:Biocenter I\, EG 00.187\, Hanns-Dieter-Hüsch-Weg 15\, Mainz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20250625T143000
DTEND;TZID=UTC:20250625T153000
DTSTAMP:20250624T125913Z
CREATED:20250528T155320Z
LAST-MODIFIED:20250624T125913Z
UID:10000102-1750861800-1750865400@crc1551.com
SUMMARY:SFB 1551 Seminar Series Event - Dr. Thomas Quail
DESCRIPTION:Talk by Dr.Thomas Quail\, EMBL Heidelberg\, Cell Biology and Biophysics Unit\n \nTitle: Molecular sociology of self-organising genomes \nAbstract: \nProteins organise the genome across multiple length and time scales. How proteins collectively bridge these scales to generate structure execute enzymatic reactions remains an open question. In this talk\, I will discuss our work on dissecting biophysical mechanisms of genome self-organization\, and how these principles are linked to transcription. To tackle these questions\, we use interdisciplinary approaches that combine single molecule biophysics\, reconstitution biology\, and theory. I will describe how protein condensation acts as an organizing principle of genome organization\, generating forces on DNA that then act as active enzymatic scaffolds. \n 
URL:https://crc1551.com/our-event/sfb-1551-seminar-series-event-dr-thomas-quail/
LOCATION:Biocenter I\, EG 00.187\, Hanns-Dieter-Hüsch-Weg 15\, Mainz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20250605T103000
DTEND;TZID=UTC:20250605T113000
DTSTAMP:20250528T135508Z
CREATED:20250314T093009Z
LAST-MODIFIED:20250528T135508Z
UID:10000093-1749119400-1749123000@crc1551.com
SUMMARY:SFB 1551 Seminar Series Event - Dr. Oleksandra Kukharenko
DESCRIPTION:Methods talk by Dr.Olksandra Kukharenko\, Max Planck Institute for Polymer Research \nTitle: Bridging Scales in Molecular Dynamics Simulations with Machine Learning \nAbstract:\nGrasping the behavior of biomolecules across diverse length and time scales is a persistent challenge in molecular biophysics. While atomistic simulations provide detailed molecular insights\, their high computational cost limits their applicability. Coarse-grained models\, on the other hand\, allow access to longer timescales and larger systems but often sacrifice resolution and accuracy. To connect these approaches meaningfully\, it is essential to develop strategies that can bridge the scales and preserve key thermodynamic properties. \nIn this talk\, I will showcase recent advances in leveraging machine learning for the analysis of free energy landscapes. I will demonstrate how tools such as dimensionality reduction and clustering can uncover key collective variables and metastable states from high-dimensional simulation data. Moreover\, I will explore how these learned representations can facilitate the transfer of insights between different modeling resolutions\, enabling seamless integration of coarse-grained and atomistic simulations. Applications to systems with complex multi-body interactions will illustrate the power of this multiscale\, data-driven perspective. \n 
URL:https://crc1551.com/our-event/sfb-1551-seminar-series-event-dr-oleksandra-kukharenko/
LOCATION:Biocenter I\, EG 00.187\, Hanns-Dieter-Hüsch-Weg 15\, Mainz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20241212T103000
DTEND;TZID=UTC:20241212T113000
DTSTAMP:20241209T162017Z
CREATED:20241114T171620Z
LAST-MODIFIED:20241209T162017Z
UID:10000082-1733999400-1734003000@crc1551.com
SUMMARY:SFB 1551 Seminar Series Event - Helle Ulrich
DESCRIPTION:Getting to know the ubiquitin family – analysis & manipulation \nPosttranslational modifications of proteins play essential regulatory roles in cells as they modulate their targets’ interactions\, localization\, and stability. This is achieved either by changing the biophysical properties of the targets or by providing interaction surfaces for dedicated receptors that elicit a biological signal. In this lecture\, I will give a brief overview over the family of ubiquitin-like modifiers\, their biochemical and biological properties\, their enzymatic machinery\, and their signalling functions in the cell. I will also cover established and innovative techniques to analyse and manipulate their activities in cells.
URL:https://crc1551.com/our-event/sfb-1551-seminar-series-event-helle-ulrich/
LOCATION:Biocenter I\, EG 00.187\, Hanns-Dieter-Hüsch-Weg 15\, Mainz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20241205T103000
DTEND;TZID=UTC:20241205T113000
DTSTAMP:20240912T155211Z
CREATED:20231122T103437Z
LAST-MODIFIED:20240912T155211Z
UID:10000049-1733394600-1733398200@crc1551.com
SUMMARY:SFB 1551 Seminar Series Event - René Ketting
DESCRIPTION:Talk announcement for René Ketting.
URL:https://crc1551.com/our-event/sfb-1551-seminar-series-event-rene-ketting/
LOCATION:Biocenter I\, EG 00.187\, Hanns-Dieter-Hüsch-Weg 15\, Mainz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20240919T103000
DTEND;TZID=UTC:20240919T113000
DTSTAMP:20240912T140451Z
CREATED:20231122T103609Z
LAST-MODIFIED:20240912T140451Z
UID:10000050-1726741800-1726745400@crc1551.com
SUMMARY:SFB 1551 Seminar Series Event - Dirk Schneider & Nadja Hellmann
DESCRIPTION:Isolating and characterizing proteins for in vitro condensate formation might be problematic! \nHave you ever worked with isolated proteins? Most work in our group involves the isolation of (typically recombinantly produced) proteins plus their biophysical characterization. During this work\, we encountered several problems associated with the insolation of tagged proteins and/or with their biophysical characterization. We have therefore decided to discuss some problems that typically occur but are often ignored “hands on”. We will focus on the isolation of tagged proteins plus their characterization via CD spectroscopy and/or dynamic light scattering. We will use examples from our own research with a condensate-forming protein to highlight some problems and pitfalls.
URL:https://crc1551.com/our-event/sfb-1551-seminar-series-event-dirk-schneider/
LOCATION:Hanns-Dieter-Hüsch-Weg 15\, Mainz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20230914T090000
DTEND;TZID=UTC:20230914T110000
DTSTAMP:20230906T074757Z
CREATED:20230602T104734Z
LAST-MODIFIED:20230906T074757Z
UID:10000018-1694682000-1694689200@crc1551.com
SUMMARY:SFB 1551 Seminar Series Event - Svenja Morsbach
DESCRIPTION:Talk announcement for Svenja Morsbach
URL:https://crc1551.com/our-event/sfb-1551-seminar-series-event-svenja-morsbach/
LOCATION:Biocenter I\, EG 00.187\, Hanns-Dieter-Hüsch-Weg 15\, Mainz
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20230824T090000
DTEND;TZID=UTC:20230824T110000
DTSTAMP:20230801T125717Z
CREATED:20230626T063436Z
LAST-MODIFIED:20230801T125717Z
UID:10000031-1692867600-1692874800@crc1551.com
SUMMARY:SFB 1551 Seminar Series Event - Martin Girard
DESCRIPTION:Talk announcement of Martin Girard \n————————————————————————————————————————————————- \n*From lead to cells: digital alchemy\, multicomponent mixtures\, and chemical regulation* \nby Dr. Martin Girard \nMax-Planck-Institute for Polymer Research
URL:https://crc1551.com/our-event/sfb-1551-seminar-series-event-martin-girard/
LOCATION:Biocenter I\, EG 00.187\, Hanns-Dieter-Hüsch-Weg 15\, Mainz
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DTSTART;TZID=UTC:20230502T100000
DTEND;TZID=UTC:20230502T180000
DTSTAMP:20230512T071014Z
CREATED:20230417T104033Z
LAST-MODIFIED:20230512T071014Z
UID:10000010-1683021600-1683050400@crc1551.com
SUMMARY:SFB 1551 Seminar Series Event - Lin Guo & Rohit Pappu
DESCRIPTION:Professors Lin Guo and Rohit Pappu will visit for a talk on May 2\, 2023. \n\n*Hidden complexities of condensates formed by simple systems* \nAbstract: \nApplication of the physics of associative macromolecules has led to growing recognition that condensates\, even of relatively simple systems\, form via hierarchies of processes governed by sequence-encoded molecular grammars that go beyond LLPS. The talk will present data and results from experiments and simulations that highlight the importance of phase separation coupled to percolation for systems governed by homotypic interactions\, and the relevance of the coupling between microphase and macrophase separation in systems where homotypic and heterotypic interactions work together. Broader implications for complex multicomponent systems will also be discussed. \nby Professor Rohit Pappu \nWashington University in St. Louis \nDepartment of Biomedical Engineering \n  \n*Reversing Aberrant Phase Transitions of ALS-linked Disease Protein: FUS* \nAbstract: \nLiquid-liquid phase separation (LLPS) mediates the formation of diverse membraneless organelles\, such as stress granules (SGs) in the cytoplasm. Despite clear biological utility\, dysregulated liquid-liquid phase separation can be detrimental. For example\, phase-separated stress granules enrich RNA-binding proteins (RBPs)\, such as TDP-43 and FUS\, which have an intrinsic tendency to form fibrils that are closely tied to fatal neurodegenerative disorders\, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Therefore\, it is important to understand how cells regulate the liquid-liquid phase separation of biomolecular condensates\, which includes maintaining beneficial phases and simultaneously preventing pathological phase separation and fibrillization. As RNA-binding proteins localize mainly in the nucleus\, the phase separation of FUS and TDP-43 can be regulated by both nuclear import receptors and short RNAs. For example\, we found that phase separation of FUS can be regulated by Karyopherinβ2 (Kapβ2)\, which recognizes the proline/tyrosine–nuclear localization signal (PY-NLS) at the C-terminus of FUS protein. On the other hand\, phase separation of TDP-43 can be regulated by the Importina/Karyopherinb1 complex\, which binds to the canonical NLS of TDP-43. In vivo\, Kapβ2 prevents FUS accumulating in stress granules\, restores nuclear FUS localization and function. By preventing and reversing aberrant FUS phase transition and cytoplasmic localization\, Kapβ2 is able to rescue neurodegeneration caused by disease-linked FUS. Our results indicate that regulating FUS LLPS by nuclear import receptors could be potential therapeutic strategy for ALS/FTD. \nby Professor Lin Guo \nThomas Jefferson University \nDepartment of Biochemistry and Molecular Biology \nLinGuo_RohitPappu_Talk_Announcement_02052023
URL:https://crc1551.com/our-event/sfb-1551-seminar-series-event/
LOCATION:Biocenter I\, EG 00.187\, Hanns-Dieter-Hüsch-Weg 15\, Mainz
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