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DTSTART;TZID=UTC:20230125T170000
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SUMMARY:Colloquium "Macromolecular Sciences" and the SFB 1551 - Evan Spruijt
DESCRIPTION:Talk announcement for the colloquium “Macromolecular Sciences” and the SFB 1551 \n\n*Coacervates as organisers of biomolecular chemistry* \nEvan Spruijt \nInstitute for Molecules and Materials \nRadboud University\, Nijmegen \n\nAbstract: \nCoacervates are condensed liquid-like droplets that can be\nformed with molecules ranging from short peptides and\nnucleotides to long polymers through liquid-liquid phase\nseparation. They have been studied extensively in colloid and\ninterface science for their remarkable materials properties\,\nand now receive increasing attention as in vitro models\nmimicking biomolecular condensates.[1] Moreover\, their\nability to sequester a wide range of biomolecules creates a\nbroad range of opportunities for synthetic cell applications.\nHowever\, challenges remain to control phase separation in\ncrowded environments\, to tune interactions between\ncoacervates and with membranes\, and to tailor coacervates\nfor specific functions. In this talk\, we will focus on addressing\nthese three key challenges by answering the following\nquestions:\n(i) How does the cellular environment affect the formation and\nproperties of biomolecular condensates and other\ncoacervates?[2\,3] (ii) How do coacervates interact with each\nother and with membranes?[4] (iii) How do coacervates\ninfluence the self-assembly and aggregation of proteins?[5] \nReferences\n[1] Coacervates as models of membraneless organelles.\nYewdall\, N.A.\, André\, A.A.M.\, Lu\, T. and Spruijt\, E.\, Curr. Opin. Colloid Int. Sci. (2021)\, 52\, 101416.\n[2] Crowding-induced phase separation and gelling by co-condensation of PEG in NPM1-rRNA condensates.\nAndré\, A.A.M.\, Yewdall\, N.A. and Spruijt\, E.\, Biophys. J. (2022)\, in press.\n[3] ATP:Mg2+ shapes condensate properties of protein-RNA condensates and their partitioning of clients. Yewdall\, N.A.\,\nAndré\, A.A.M.\, Van Haren\, M.H.I.\, Nelissen\, F.H.T.\, Jonker\, A. and Spruijt\, E.\, Biophys. J. (2022)\, 121\, 3962-3974.\n[4] Endocytosis of coacervates into liposomes. Lu\, T.\, Liese\, S.\, Schoenmakers\, L.\, Weber\, C.A.\, Suzuki\, H.\, Huck\, W.T.S. and\nSpruijt\, E.\, JACS (2022)\, 144\, 13451-13455.\n[5] Biomolecular condensates can both accelerate and suppress aggregation of α-synuclein. Lipiński\, W.P.\, Visser\, B.S. Robu\,\nI.\, Abolghassemi Fakhree\, M.M.\, Lindhoud\, S.\, Claessens\, M.M.A.E. and Spruijt\, E.\, Science Advances (2022)\, 8\, abq6495.
URL:https://crc1551.com/our-event/colloquium-macromolecular-sciences-and-the-sfb-1551/
LOCATION:MPI-P Lecture Hall\, Ackermannweg 10\, Mainz
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