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DTSTART;TZID=UTC:20230616T100000
DTEND;TZID=UTC:20230616T110000
DTSTAMP:20230602T103237Z
CREATED:20230509T061508Z
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UID:10000015-1686909600-1686913200@crc1551.com
SUMMARY:Joint SFB 1551 & SFB 1361 Seminar Series Event - Matthias Altmeyer
DESCRIPTION:Talk announcement of Matthias Altmeyer \n\n*Dynamics and Functions of DNA Repair Compartments* \nAbstract: \nGenome stability is constantly challenged by reactive byproducts of\ncellular metabolism and environmental toxins. Dedicated repair pathways\nhave evolved to deal with DNA damage\, and their malfunctioning is\nassociated with human diseases such as cancer and neurodegeneration.\nElucidation of the hierarchy and temporal order in which DNA damagesensing\nproteins as well as signaling and repair factors assemble around\nDNA lesions has painted a complex picture of tightly regulated\nmacromolecular interactions that build specialized nuclear compartments\nto facilitate repair and maintain genome integrity. While many of the\nunderlying interactions\, e.g. between repair factors and damage-induced\nhistone modifications\, can be explained by lock-and-key or induced fit\nbinding models assuming fixed stoichiometries\, structurally less well\ndefined interactions\, such as the highly dynamic multivalent interactions\nimplicated in biomolecular condensate formation by phase separation\,\nalso participate in the formation of multi-protein assemblies at sites of\nDNA damage. In this seminar\, a summary and an update will be provided\non efforts to characterize and better understand the dynamics and\nfunctions of cellular DNA repair compartments and how they coordinate\nmaintenance of genome integrity in space and time. \n  \nby Prof. Dr. Matthias Altmeyer \nUniversity of Zurich \nDepartment of Molecular Mechanisms of Disease \n\nTalk_Announcement_Altmeyer
URL:https://crc1551.com/our-event/sfb-1551-seminar-series-event-matthias-altmeyer/
LOCATION:Seminar room 2nd floor\, Ackermannweg 4\, Mainz\, Germany
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