SFB1551 Project: R05

Project Title: : A Biomimetic Supramolecular Approach to Mimic Protein–RNA Networks

Summary: The project uncovers how RNA-binding proteins (RBPs) use modular architectures—structured domains and intrinsically disordered regions—to regulate RNA recognition. To investigate protein–RNA binding phenomena and dynamic conjugation strategies on multivalent synthetic polymer scaffolds we established non-covalent host–guest complexation as a versatile crosslinking motif enabling the formation of supramolecular networks under physiological conditions.