SFB 1551 Seminar Series Event – Prof. Dr. Pol Besenius

Methods talk by Prof. Dr. Pol Besenius, Chemistry Department, Johannes Gutenberg University

Weak Non-Covalent Interactions in Biopolymer and Synthetic Supramolecular Assemblies

This lecture introduces the basic principles that define modern supramolecular chemistry through a historical and conceptual overview of non-covalent interactions. We will examine the nomenclature and evolution of key interaction types, including hydrogen bonding, Coulomb interactions, π–π stacking and related interactions in aromatic systems. Emphasis will be placed on understanding how enthalpic and entropic contributions govern the formation, strength, and selectivity of supramolecular assemblies. Finally, we will explore the crucial role of the solvent environment—highlighting solvation and solvophobic effects in (macro)molecular recognition and self-assembly. These elements provide a framework for analyzing and designing non-covalent systems across chemistry, biology, and materials science.