We are excited to announce that Shikha Dhiman just joined the SFB1551 as fully funded member with project entitled “Covalent and Non-Covalent Macromolecular Approach for Precision and Switchable Protein Oligomerization: Exploring Fundamental Insights and Control Cellular Functions”
“In summary, our research aims to uncover the underlying principles on the impact of oligomerization on protein function, from the fundamental properties to biologically relevant consequences. By combining macromolecular, biophysical, and biochemical approaches, we aspire to contribute to the advancement of our understanding of cellular processes and the development of innovative tools for future applications.” (Shikha Dhiman in the SFB1551 project proposal)
Shikha Dhiman (JGU) was already actively involved in the SFB1551 since 2023 as associate PI. Following the submission and approval of her follow-up project proposal within the SFB1551, we now look forward to seeing her science progress even faster!
Congratulations!
Figure 1. Schematic illustration of this proposal on the example of NPM1. This proposal aims to use a macromolecular chemistry approach to 1. Develop a model system to study protein oligomerization, 2. Understand the protein oligomer-function relationship, and 3. Modulate protein activity. A1-3 = Acidic regions-3; B1-2 = Basic regions 1-2; OD = Oligomerization Domain; NBD = Nucleic Acid-Binding Domain; IDR = Intrinsically Disordered Region of NPM1.