SFB1551 Project: R13

Project Title: Computational investigation of evolution and sequence context of Arginine/Glycine-rich sequences

Summary: Arginine/Glycine-rich (RG-rich) sequences in proteins have become an interesting field of research due to their abundant appearance across many proteomes, as well as their diverse functionalities, such as their driving character in phase separation, the formation of membrane-less organelles (MLOs) or their role in transcription, DNA damage signaling, pre-mRNA splicing ,mRNA translation and other DNA/RNA processing functions. Their evolution and their complex sequence context are not understood and with a large-scale, systematic, computational study, I want to refine the definition of RG-rich sequences, find subgroups of RG-rich motifs, and understand evolution and context to be able to manipulate and predict RG-functionality.