Joint SFB 1551 & SFB 1361 Seminar Series Event – Matthias Altmeyer

Talk announcement of Matthias Altmeyer

*Dynamics and Functions of DNA Repair Compartments*

Abstract:

Genome stability is constantly challenged by reactive byproducts of
cellular metabolism and environmental toxins. Dedicated repair pathways
have evolved to deal with DNA damage, and their malfunctioning is
associated with human diseases such as cancer and neurodegeneration.
Elucidation of the hierarchy and temporal order in which DNA damagesensing
proteins as well as signaling and repair factors assemble around
DNA lesions has painted a complex picture of tightly regulated
macromolecular interactions that build specialized nuclear compartments
to facilitate repair and maintain genome integrity. While many of the
underlying interactions, e.g. between repair factors and damage-induced
histone modifications, can be explained by lock-and-key or induced fit
binding models assuming fixed stoichiometries, structurally less well
defined interactions, such as the highly dynamic multivalent interactions
implicated in biomolecular condensate formation by phase separation,
also participate in the formation of multi-protein assemblies at sites of
DNA damage. In this seminar, a summary and an update will be provided
on efforts to characterize and better understand the dynamics and
functions of cellular DNA repair compartments and how they coordinate
maintenance of genome integrity in space and time.

by Prof. Dr. Matthias Altmeyer

University of Zurich

Department of Molecular Mechanisms of Disease

Talk_Announcement_Altmeyer