Protein aggregation into fibres inside cells is an ever-present process associated with human disease, but...
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In this project, the dynamics of light-activated formation of condensates of splicing regulatory proteins will... -
DNA is the largest biopolymer in nature with a length of up to 10Â cm (human... -
The post-translational modifiers ubiquitin and SUMO, two small, conserved proteins known for their ability to... -
Whereas our genome is localized in the membrane-enclosed nucleus, membrane-less compartments within the nucleus further... -
Proteins in nature exhibit diverse structures and sizes, some preferring to exist as monomers, while... -
The long-term goal of this project is to establish biopolymer-based protonuclei compartments as a viable... -
Targeted protein degradation can be enhanced by compartmentalizing protein degradation through the formation of proteolytic... -
The stabilization, remodelling, and repair of biological membranes are critical tasks by which eukaryotic cells... -
The coordination module will be supervised by the designated spokesperson and the designated management committee.... -
In this project, we will establish a service platform for the production and engineering of... -
Biological systems often rely on switch-like all-or-nothing responses. These regulatory switches are based on feedback... -
Germ cells are characterized by various membrane-less organelles, collectively named germ granules. These contain many... -
The Integrated Research Training Group (IRTG) is a structured PhD programme that aims to train... -
Signal transmission between neurons takes place at specifically designed contact sites called synapses. Successful transmission... -
The compaction of our two-meter-long genome into a confined micron-sized nuclear volume creates numerous challenges... -
Whereas in vitro studies (here referring to studies using purified components) can provide molecular insights,... -
Block co-polymers are comprised of multiple homopolymer regions that enable the design of polymer materials... -
Post-translational modifications (PTMs) play an important role in modifying protein function and cell physiology, but...